Drew Barrymore has been cast as the lead voice in South of the Border, a Walt Disney Pictures comedy being directed by Raja Gosnell.

Also lending their voices to the live-action movie in which the animals talk is a who’s who of Latino actors including Andy Garcia>, Salma Hayek, George Lopez, Cheech Marin, Paul Rodriguez, Placido Domingo, Edward James Olmos and Eddie “Piolin” Sotelo.

“South” chronicles the adventures of a pampered Beverly Hills chihuahua named Chloe (Barrymore) accustomed to riding in a purse. While on vacation in Mexico, she gets lost and must rely on her friends to help her get back home.

Garcia is playing a German shepherd who was kicked off the police force because he lost his sense of smell and has now given up on life. Hayek is Chloe’s spirit guide who helps her find her true heritage.

Lopez is Papi, a macho romantic Chihuahua who will do anything for the love of Chloe. Piper Perabo was previously cast as the Chloe’s human owner searching for her lost pet.

Barrymore, whose recent credits include “Lucky You” and “Music and Lyrics,” has done voice work in the past, having been heard in last year’s “Curious George” as well as on TV’s “Family Guy.”